Blood Vessel Attack May Spark Brain Inflammation in Long COVID (and ME/CFS)
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This model is all the more interesting because it appears to fit what some past ME/CFS studies have found. Baraniuk’s 2005 cerebrospinal proteome study found evidence of amyloid (misfolded protein) deposition in the blood vessels and a weakening of the blood vessel walls in the brain. Baraniuk speculated that localized bleeding caused by amyloid deposition into the blood vessels might be occurring throughout ME/CFS patients’ brains.
Back in 1992, a large study co-authored by Dr. Peterson, Dr. Cheney, Dr. Komaroff, and Dr. Paul Gallo, found widespread punctate hyperintensities in the brains of people with ME/CFS. The authors stated that these punctate hyperintensities corresponded to the perivascular spaces surrounding the cerebrospinal fluid and suggested that a similar process had occurred: leakage had ignited an inflammatory response in the brain that damaged the neurons. As with Nath’s findings, the location of the hyperintensities varied by patient. Punctate hyperintensities are now believed to be caused by microvascular disease; i.e. damage to the small blood vessels in the brain – exactly what Nath has found."