Recently published ME/CFS research



  • In keeping with the theme of this category, recently published and notable scientific publications can be posted here.

    For those who wish to keep up with all of the recent work being done in the field of ME/CFS you can sign up to the Emerge Australia Research Digest where we send out a fortnightly e-newsletter with summaries of some of the latest research and information about ME/CFS. To sign up click here.



  • A hierarchical logistic regression predicting rapid respiratory rates from post-exertional malaise

    Author: Cotler J, Katz BZ, Reurts-Post C, Vermeulen R, Jason LA (DePaul University, USA)
    Link: https://www.tandfonline.com/doi/abs/10.1080/21641846.2020.1845287?journalCode=rftg20

    This recently published study examined the possible predictors of tachypnea (rapid respiratory rates) in ME/CFS. The authors' findings suggest that respiratory rate may be useful as an objective clinical metric of PEM, and potentially ME/CFS, but the limitations of this study mean that more research is required.

    Click here to view the latest Research Digest


  • Global Moderator

    I thought this was an interesting study. They decided to focus on tachypnea (rapid respiratory rate) rather than hyperventilation, because hyperventilation is often associated with psychosomatic conditions, which could then be a confounding factor.

    It’s a shame that they didn’t confirm the ME/CFS diagnosis, and just relied on the physician-reported diagnosis. Having well-characterised samples is so crucial for us. Without that, we’re just going to keep spinning our wheels.



  • A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction

    Authors: Sweetman E, Kleffmann T, Edgar C, de Lange M, Vallings R, Tate W (University of Otago, New Zealand)
    Link: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02533-3

    The authors of this study had previously shown that there are differences in the RNA of ME/CFS patients. This current study aimed to further their findings by determining whether there was also differences in the quantity and types of proteins expressed in the peripheral blood mononuclear cells (PBMCs, the immune cells in the blood) in ME/CFS patients.

    They found 60 proteins that were differentially expressed in the PBMC's collected from ME/CFS blood samples, compared to healthy control samples, and that many of these proteins had roles in mitochondrial function & cellular energy production.

    These findings add to the mounting evidence that mitochondrial dysfunction plays a significant role in the pathogenesis of ME/CFS.


  • Global Moderator

    @Jess_Em_Aus said in Recently published ME/CFS research:

    **A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction

    It’s great when we get research coming from Warren Tate’s lab. It’s a shame that they’re struggling so much for funding, which means that their sample size is tiny.



  • Thanks everyone for all the info and links. Always interesting.
    Here's some I was looking at recently.

    A group looking into chronic diseases:

    Article about them:
    https://www.sbs.com.au/news/insight/new-chronic-illness-team-offers-hope-to-australian-sufferers

    Their website:
    https://pandis.org/



  • @Simone_Em_Aus The other problem Warren has is logistics. These samples have to be sourced close to the lab within a certain time frame. That's a problem for much research and I think a key to this is collaboration internationally using the same methods with a well-characterized cohort. But yes - funding is everything.


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